Dekaris - side effects of anthelmintic drug with some immunomodulatory effects usually associated with overdose or long-term use. That is why dekaris can be used only on prescription, the pharmacy and buy - only on prescription.

The main action decaris

The main action decaris (active substance - levamisole) due to the destruction and elimination from the body roundworms - nematodes. Most often used to treat dekaris ascariasis.

Synthetic materials levamisole inhibits the action of certain enzymes involved in cellular metabolism of nematodes, which leads to inhibition of the neuromuscular system of the worms and their complete immobilization, and then the removal of a stool. This immobilized worms are removed from the intestine in a natural way - additional intake of laxatives or any diet is not required.

Dekaris and has some immunomodulatory effects. It stimulates the function of regulatory T-lymphocytes, which leads to the restoration of normal cellular immunity. But today, as an immunomodulator dekaris does not apply, as its effectiveness in this regard is inadequate.

Side effects decaris the central nervous system

Dekaris rarely affects the central nervous system when properly applied at the recommended doses. However, such side effects can not be excluded. Against the background of decaris may appear headache, dizziness, drowsiness or agitation, nausea, vomiting, convulsions and even dizziness. Typically, these violations are like after drug withdrawal.

Furthermore, development and possible late effects of encephalopathy. This side effect occurs in two to five weeks after stopping decaris. Manifested encephalopathy disorders of memory and consciousness, headache, dizziness, depression, decreased volitional qualities, fatigue, weakness, irritability Irritability - you try to control my temper , Distraction, tearfulness, sleep disturbances Dreams: how to understand our dreams   and so on. Typically such disorders are reversible, particularly at the earliest possible assignment of glucocorticoid hormones.

Adverse effects on the digestive organs decaris

Nausea, vomiting, diarrhea or constipation, abdominal pain Abdominal pain: Types and Symptoms   and disruption of appetite can also be a sign of negative effects decaris Dekaris - with anthelmintic drug and immunostimulatory effects   on the digestive organs. Especially dangerous decaris negative effect on the liver, so the diseases of the body, accompanied by a reduction in its function, can not appoint dekaris. Unfortunately, liver disease is sometimes asymptomatic, which leads to the appearance of side effects.

In isolated cases in patients receiving decaris may develop acute pancreatitis. But this complication is very rare, and often in a detailed examination of the patient turns out that it is not acute pancreatitis and exacerbation of latent chronic pancreatitis provoked decaris reception.

Side effects decaris from the hematopoietic system

Dekaris can have a depressing effect on the hematopoietic system. This is manifested in the form of agranulocytosis.

Agranulocytosis - a condition characterized by the complete or almost complete disappearance of granulocytes (granular white blood cells responsible for cell-mediated immunity) in the peripheral blood. Medical agranulocytosis may develop in patients receiving certain medications, including decaris.

This has major importance hypersensitive individual organism in relation to a particular matter. Agranulocytosis in the case arises from a primary lesion of peripheral blood leukocytes exposed antileykotsitarnyh autoantibodies produced by the immune system to its own white blood cells. The cause of autoimmunity is that levamisole, getting into the blood, binds to blood proteins and acquire the properties of the antigen, in response to which the body produces antibodies that destroy granulocytes.

Destruction of granulocytes leads to the fact that the body becomes vulnerable to any infection. Treatment of agranulocytosis is performed only in a hospital.

Side effects decaris of other organs and systems

When receiving decaris also possible appearance of skin rash, exacerbations of skin diseases (eg psoriasis), disorders of taste and smell, pain in muscles and joints, lipid metabolism disorders, flu-like syndrome (fever, weakness, catarrhal symptoms).

Dekaris - a drug that has a fairly significant side effects, so use it without a prescription is not necessary.

Galina Romanenko

Gastric hyperacidity may adversely affect not only the state of the stomach, but also on the state of other organs of the esophagus, intestine, liver and pancreas Diabetes and pancreas - the things you need to know . Therefore kvamatel that suppresses gastric acid secretion increased, part of the complex therapy of many diseases of the digestive system.

The mechanism of action kvamatel

Kvamatel (INN - famotidine) is an anti-ulcer drug, a blocker of histamine H2-receptor. It comes Hungarian pharmaceutical company Gedeon Richter tablets, film-coated pink (one tablet contained 20 mg or 40 mg of active compound) and as a lyophilisate for the preparation of a solution for intravenous administration with the solvent (in a single vial 72, 8 mg of lyophilisate in which contains 20 mg of active substance).

Kvamatel mechanism of action by blocking histamine H2 receptors located on the secretory cells of the gastric mucosa and transmitting stimuli to gastric acid secretion. Histamine is present in an inactive form in most body tissues. Histamine, located on the gastric glands, stimulated gastric acid secretion, while increased in gastric juice content of acid and pepsin.

Kvamatel peculiarity is that it can block the secretion of gastric juice by histamine stimulated not only, but also other substances. This allows its use in the treatment of diseases of the digestive system, accompanied by increased secretion of gastric juice, such as gastritis and gastric ulcer. Under the influence of kvamatel reduced gastric acidity and pepsin activity - acid enzyme that promotes the digestion of proteins. Thus kvamatel no significant effect on motor activity of gastric, pancreatic juice, hormones and venous circulation.

Protection of gastric mucosa is enhanced also by increasing mucus secretion in the stomach, its content of glycoproteins. The mucus also increases hydrogen content, having an alkalizing effect, and prostaglandins (these active compounds protect the gastric mucosa from lesions), which promotes healing of ulcers and erosions, stop bleeding. Kvamatel has little effect on the enzymatic activity of the liver.

After receiving tablets kvamatel effect occurs within 60 minutes after intravenous administration - after 30 minutes. Duration of action - 12-24 hours.

Indications and contraindications for use

Kvamatel taken strictly on prescription in the following diseases and conditions:

• gastric ulcer and duodenal ulcers and stomach in the acute stage, as well as for the prevention of exacerbations and bleeding;
• ulcers of the stomach and duodenum, due to the use of nonsteroidal anti-inflammatory drugs, stress and other impacts;
• when erosive gastritis with increased secretion of the stomach;
• when reflux esophagitis - inflammation of the wall of the esophagus caused by constant throwing up into the esophagus acidic stomach contents;
• when Zollinger-Ellison syndrome - a benign tumor (adenoma) of the pancreas, produce gastrin - a hormone that stimulates the formation of gastric juice; wherein in the stomach and duodenal ulcers are formed;
• functional disorders of the gastrointestinal tract (heartburn, diarrhea, abdominal pain, and so on) caused by increased secretion of gastric juice;
• to suppress gastric secretions prior to general anesthesia in order to prevent ingress of acidic stomach contents to the airways.

Kvamatel contraindicated:

• during pregnancy and nursing Breastfeeding - a personal choice   breast;
• children;
• hypersensitivity to its components of the patient.

Precautions kvamatel prescribed for severe liver and kidney impairment of their function, including cirrhosis of the liver with the defeat of the venous system and the brain. In a dramatic admission kvamatel may develop withdrawal symptoms, so treatment is stopped, gradually reducing the dose.

Side effects

Kvamatel generally well tolerated, but may occur and side effects:

• the part of the digestive system - a violation of appetite, nausea, vomiting, dry mouth, stomach pain, bloating, constipation or diarrhea, abnormal liver function, hepatitis Hepatitis - the scourge of our time , Acute pancreatitis;
• from the blood - a general decrease in the number of blood cells, including white blood cells (immunosuppression) and platelets (threat of bleeding);
• on the part of the circulatory system - heart rhythm disorders, heart block, lower blood pressure;
• the nervous system and sensory organs - headaches, dizziness, lethargy, drowsiness, decreased performance, hallucinations, confusion, blurred vision and hearing;
• hormonal disorders - increase the blood levels of the pituitary hormone prolactin, suppression of male hormones and changes in the male body of female type (gynecomastia), menstrual irregularities, decreased sex drive;
• In addition, there may be joint pain Joint pain - how to understand what is going on?   and muscle pain, hair loss, acne, allergic reactions.

Kvamatel help only if it is assigned to the doctor after the preliminary examination.

Galina Romanenko