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How does hepatitis
Acute hepatitis from any source occurs in cycles. During infectious hepatitis distinguish four periods: incubation, prodromal, icteric and convalescence. Noninfectious hepatitis also occur cyclically, but the incubation period does not have.
The incubation period for hepatitis B is 60-180 days prodrome lasts 1-2 weeks, but may be absent. Manifestation of hepatitis in this period depends on the severity. Temperature hepatitis often high, but asymptomatic or may not rise at all. Characterized by headaches, joint and muscle pain with hepatitis, abdominal pain
Abdominal pain: Types and Symptoms
and in the right hypochondrium. The most characteristic symptom of this period is to increase the blood levels of liver enzymes (ALT and AST)
During the height of the disease (icteric period) lasts about a month and is characterized by jaundice staining of the skin, dark urine and discolored feces, as well as the emergence of direct bilirubin in the blood and urine urobilin. The patient is braked, concerned about pain in the liver and strong itching. Eruptions hepatitis are hemorrhagic in nature - petechial hemorrhages (petechiae), spider veins (telangiectasia), bruising.
The period of convalescence lasts from one to 12 weeks, the patient's condition is gradually recovering, but can pass the disease to a chronic form. Liver pain with exacerbation of hepatitis B is a typical manifestation of this process.
But sometimes it gets for hepatitis fulminant character (fulminant hepatitis). Hepatitis is the most dangerous since it is very rapid, with acute hepatic failure, and coma, often leads to death of the patient. Disease manifested by various disorders of the central nervous system caused by intoxication. Initially, there is an unstable mood, then aggressiveness, hallucinations, sometimes - seizures, confusion, loss of consciousness, coma. From the mouth of the patient there is a characteristic smell of rotten apples, because of the destruction of the blood vessels hemorrhage occur in various organs, there is vomiting color of coffee grounds, black stools.
Symptoms of hepatitis B can be erased, possibly asymptomatic hepatitis.
Hepatitis may be complicated by the development of ascites - an accumulation of fluid in the abdominal cavity. Ascites hepatitis develops due to compression of the blood vessels of inflamed liver tissue or overgrown by connective tissue. In the latter case, the growth of connective tissue is reversible (fibrosis), and with proper treatment of ascites passes. If the patient is not receiving adequate treatment, the connective tissue is fully formed and mature liver cirrhosis - an irreversible condition in which ascites will grow. Hepatitis and cirrhosis related condition: for any type of hepatitis are at risk of developing cirrhosis of the liver with a progressive decrease in function of the body.
Chronic hepatitis in most cases goes unnoticed. The main symptom is weakness, and decreased performance. Exacerbation of chronic hepatitis accompanied by increased itching of the skin, the appearance of jaundice staining of the skin and mucous membranes (especially pronounced yellow sclera - is the earliest sign of exacerbation), dark urine and feces discolored. It is also a sign of acute liver enlargement and increased her pain.
Diagnosis of hepatitis
If you suspect a hepatitis patient passes full inspection: ultrasound of the abdomen, if necessary - MRI and CT. But the main diagnostic methods are laboratory studies, on which the differential diagnosis of hepatitis.
The general analysis of blood, urine and faeces in hepatitis
In general, a blood test for hepatitis can be seen decreased hemoglobin, decreased the content of leukocytes and platelets and clotting disorders, acceleration of ESR,
General urine test can detect it urobelina - gall pigment, which appears in the urine with abnormal liver function. Urine is brown. Kal hepatitis discolored
Biochemistry hepatitis has the following features:
- increase of liver enzymes (alanintransaminaza - ALT and aspartate aminotransferase - AST), also increases blood levels of alkaline phosphatase (ALP) and glutamyl transferase (GGT);
- increase blood levels of total and direct (related) bilirubin; when the concentration of bilirubin in the serum of more than 27 - 34 mmol / l jaundice (mild form - up to 85 mol / l, mid - 86 - 169 mmol / l, severe - more than 170 micromol / l);
- Dysproteinemia - a violation of the ratio of serum protein fractions: albumin decreases and increases gammaglobulins;
- elevated levels of triglycerides in the blood - major blood lipids (the rate depends on the age and sex).
All patients with hepatitis sure blood is taken to identify infectious agents using polymerase chain reaction (PCR), which may be qualitative and quantitative. PCR method is highly specific, it can be used to identify the presence in the blood of even a single virus. PCR method can detect hepatitis viruses and their antigens.
Immunoassays for hepatitis can detect antibodies to all hepatitis viruses. In addition, the detected antibodies to their own tissues of the liver - they appear in patients with autoimmune hepatitis.
It is also possible conduct of express - analysis of hepatitis using special test strips. Thus blood can detect antigens B (surface antigen HBsAg) and antibodies to the virus C (HCV) in blood and saliva. Tests can be conducted at home.
To clarify the status of a liver biopsy is performed histological examination of material taken from the liver under ultrasound guidance. This allows to identify sites of inflammation, necrosis, the degree of proliferation of connective tissue, and so forth, that is, to assess the condition of the liver.
There are also tests that replace the histological examination of liver tissue. Hepatitis test provides a measure of liver damage, the activity of the inflammatory process by specific biomarkers venous blood.
Prevention of hepatitis
Prevention of hepatitis A and E is frequent hand washing, careful processing of fruits and vegetables, shellfish used only after cooking. State prevention of hepatitis E is constant control over the quality of tap water.
Prevention of hepatitis B - is timely vaccination, no promiscuity, use of condoms and only disposable syringes as well have been prevented and the rest of hepatitis with parenteral route of transmission.
Prevention of toxic hepatitis
Toxic hepatitis - the impact of harmful substances on the liver
- The timely interruption of the contact with the substance that caused changes in the liver.
A few facts about hepatitis
According to the World Health Organization:
- 1, 4 million cases of hepatitis A
Hepatitis A - do not forget to wash your hands!
registered annually.
- 2 billion people (estimated) around the world at one time or another have been infected with hepatitis B.
- In the world of living, at least 130 million people with chronic hepatitis C
Chronic hepatitis C - creeps imperceptibly
Among them, about 9 million - in Europe.
- Each year, about 1, 5 million people die from hepatitis B or C.
- July 28, 2011 marks the first day vmemirny established by WHO to combat hepatitis.
Galina Romanenko