Irunine - an effective antifungal drug of a new generation. The preparation is simple and easy to use, affordable price and has virtually no side effects. Available in the form of vaginal tablets, which is useful for the treatment of thrush Treating Thrush: how to get rid of bad fungus And in the form of tablets for oral administration.

Structure and Composition

The main active ingredient is itraconazole Irunine. Tablets for oral administration contain 100 mg of itraconazole for 6, 10 and 14 tablets in the package. Vaginal tablets contain 200 mg of itraconazole and are available in 6 tablets per pack. Additional ingredients: sucrose, corn starch, hydrolysed starch syrup, hypromellose and macrogol, titanium dioxide, poloxamer.

pharmachologic effect

Active ingredient - Itraconazole - triazole derivative, a synthetic antifungal agent broad spectrum. The mechanism of action is associated with inhibition of the synthesis of ergosterol - an important component of the fungal cell membrane. The drug is active against dermatophytes, yeasts Candida spp, as well as fungi.

Clinical outcomes Irunine become apparent 2-4 weeks after discontinuation of therapy in case of fungal infections of the skin and 6-9 months after cessation of treatment of onychomycosis.

Indications for Irunine

The drug is indicated for the treatment of fungal infections caused by susceptible pathogens to it:

• vulvaginalny candidiasis;
• fungal infections of the skin, mouth, eyes;
• onychomycosis caused by dermatophyte and / or yeasts;
• systemic candidiasis, including aspergillosis, cryptococcosis, histoplasmosis, sporotrichosis, parakoktsidiodoz, blastomycosis and others.

As prescribed Irunine?

Irunine appointed interior immediately after a heavy meal, swallow the tablet whole .  For genital candidiasis drug administered in doses of 200 mg two times a day for days or 200 mg 1 time per day for three days .  When pityriasis versicolor dose is 200 mg 1 time per day during the week .  Dermatomycoses treated for 15 days at a dosage of 100 mg 1 time per day .  In the event of damage to the skin of hands and feet, additional treatment is carried out for a further 15 days in the same dose .  If oral candidiasis Irunine take 100 mg one time a day for 15 days .  In the case of fungal keratitis drug is given at 200 mg 1 time per day for three weeks .  In onychomycosis drug is given at 200 mg daily for three months or repeat courses of treatment, assigning Irunine 200 mg 2 times a day for 1 week followed by a break .  In the systemic aspergillosis drug is given at a dose of 200 mg 1 time a day for 2-5 months, if necessary, increase the dose to 200 mg twice a day .  In the systemic candidiasis Irunine take 100-200 mg 1 time a day at least three weeks and not more than seven months, if necessary, increase the dose to 200 mg 2 times a day .

Side effect

• The gastro-intestinal tract and liver

Dyspepsia (nausea, vomiting), abdominal pain Abdominal pain: Types and Symptoms , Constipation, transient increase in transaminases in the blood, in some cases, hepatitis Hepatitis - the scourge of our time .

• From the nervous system

Headache, dizziness, Dizziness - if the ground is slipping from under his feet In some cases, peripheral neuropathy.

• Allergic reactions

Pruritus, urticaria, angioedema shock.

• Dermatological reactions

The rash rarely alopecia (hair loss), Stevens-Johnson syndrome.

• Other

Dysmenorrhea, hypokalemia, edema (long-term treatment).

Contraindications to receive Irunine

Main contraindications:

• Hypersensitivity to itraconazole or any other ingredients of the formulation;
• simultaneous intake of terfenadine, astemizole, tsisparida, midazoloma or triazole.

With extreme caution drug prescribed during pregnancy and breast-feeding when the effect of therapy outweighs the possible damage to the fetus or child.

Anna Sozinova

Some women believe that if a pregnancy does not occur, better to resort to folk remedies. In particular, there are folk remedies for treating endometriosis. But, unfortunately, they are not effective, since in order to cure any disease, you must first make a correct diagnosis, but it can only make a gynecologist.

Diagnosis of infertility in endometriosis

Endometriosis is often associated with infertility that causes a woman to seek a way out of this situation. Of course, most modern women treated with this problem to the doctor, but some women are trying to cope with her own. This can lead to disastrous results, since endometirioz in women of childbearing age have a tendency to spread during each menstrual cycle. This reduces the possibility of more and more women become pregnant and give birth to a child.

Gynecologist already during the consultation may suspect endometriosis in a woman in her complaints and the results of the pelvic exam Gynecological examination: an important component of women's health . But sometimes detect the disease at the first consultation is impossible. In this case, to find out the cause of infertility can help diagnostic tests. First of all, conduct laboratory research hormonal women and ultrasonography (US) of the pelvic organs and the uterus (the latest research Policy Pay using a vaginal probe). The combination of hormonal disorders Hormonal disorders - oversupply and a lack of equally dangerous   with patches of endometriosis in the internal and external genital organs are usually confirm the diagnosis.

But in some cases this is not enough, it is also carried out inspection of the inner surface of the vagina, cervix and uterus using optical equipment (colposcopy and hysteroscopy). Sometimes, to clarify the diagnosis requires X-ray examinations (hysterography), computer and magnetic resonance tomography.

For suspected endometriosis, a woman must undergo a full examination in order to identify lesions in other organs and tissues. These centers must be identified and removed.

Treatment

After the final diagnosis of the disease and identify all pathological lesions, developed a treatment plan woman. Usually, a combination of conservative and surgical treatment, which will allow it to continue to have children.

First of all, restore hormonal balance and normal, biphasic woman's menstrual cycle. Modern drugs allow this. If significant hormonal changes and endometriosis spreads rapidly, then to treat infertility Infertility Treatment - What principles are priority   used drugs - analogues Riesling-hormones of the hypothalamus. Introduction of such a drug is sustained suppression of the secretion of pituitary hormones, which in turn results in a complete suppression of the menstrual cycle. This allows you to stop the proliferation of sites of endometriosis Endometriosis - a serious problem with serious consequences And sometimes cause them to reverse the development. After stopping treatment with drugs such menstrual cycle recovers.

But more on the background of conservative treatment operation is conducted removal of endometriosis. Operations typically carried out using endoscopic equipment to enable a maximum organ sparing surgery. With this operation pathological lesions are removed, for example, through the vagina using a hysteroscope (if pathological center located in the wall of the uterus).

If pathological focus is in the fallopian tube or ovary, then you can remove it using a laparoscope, while on the front abdominal wall is several punctures, which are introduced through the light fixture and micro tools for the surgery. Laparoscopic surgery avoids the cut tissue that is associated with the subsequent development of adhesions that can certainly damage the development of the pregnancy.

Once again, the operation is assigned to an individual course of hormone therapy, which aims - to restore normal menstrual cycle and the suppression of the possible recurrence of the disease.

Is the treatment of infertility in endometriosis

If endometriosis is not combined with a congenital anomaly of the genital organs (namely at such anomalies often develop menstrual irregularities) and revealed in not running stage, the effectiveness of modern treatments conducted correctly is very high. According to some studies, it reaches 80-90%. So much depends on the woman: she must as soon as possible contact with the problem to the doctor.

Galina Romanenko