- Buserelin - helps cancer
- As produced by the female sex hormones
As produced by the female sex hormones
Female sex hormones (estrogen and progesterone) produced in the ovaries under the influence of hormones that are released in the main endocrine glands - the pituitary gland located in the brain. The pituitary gland releases follicle-stimulating (FSH) and luteinizing (LH) hormones, which are in different phases of the menstrual cycle, providing in the first half of the cycle precedence production of estrogen and the growth of follicles in the ovaries (FSH), and in the second half - progesterone and ovulation (LH).
The pituitary gland, in turn, is influenced by the area of the brain responsible for the activities of the entire endocrine system - the hypothalamus. The hypothalamus produces gonadotropin-releasing hormone (GnRH), which stimulates the production of FSH and LH. GnRH secretion is not constant, and at regular intervals, different in men and women. The introduction of synthetic long-acting GnRH analogues initially causes increased production of FSH and LH, and then a sharp decline in their production, which in turn leads to a reduction of estrogen and progesterone. If administered GnRH in a rhythm corresponding to the natural, it provides strong stimulation of sexual hormones.
Female sex hormones are produced in the male (in the testicles), providing the production and maturation of sperm. Additional chronic administration of GnRH in men suppresses the production of both female and male (testosterone) hormones.
The mechanism of action of buserelin
Buserelin - a synthetic analogue of gonadotropin-releasing hormone (GnRH), which is used in the treatment of hormone-dependent tumors. By acting on the pituitary gland, buserelin causes a transient increase in the level of sex hormones in the blood. After two weeks of continuous use occurs persistent suppression of FSH and LH, which leads to suppression of the production of sex hormones.
As a result, women sharply decreases blood levels of the main estrogen
Estrogen - the key to bone health
estradioda (the number of its women of childbearing age becomes the same as in menopause) and men - blood levels of testosterone (the amount corresponds to the state after castration, that is actually happening pharmacological castration).
When hormone dependent tumors (breast cancer, prostate cancer and others.) Sex hormones stimulate the growth of tumors, thus requiring suppression of their generation.
Buserelin is discharged in droplet form and metered nasal sprays, suspensions for intramuscular injection of long-acting injectable solution.
Indications and contraindications for use
The indication for the use of buserelin is the presence of hormone-dependent diseases:
- prostate cancer;
- breast cancer;
- endometriosis (the state before and after surgery);
- uterine fibroids;
- endometrial hyperplasia (overgrowth of the mucous membrane of the uterus).
In addition, buserelin is used to treat infertility: in vitro fertilization require complete suppression of its own hormonal activity of women in order to artificially create a managed process of oocyte maturation.
Contraindications buserelina are hypersensitivity to the drug, condition after surgical removal of the testicles in males, pregnancy, breast-feeding
Breastfeeding - a personal choice
feeding (inhibits the production of hormones necessary for development of pregnancy and development of breast milk), violation of patency of the urinary tract, metastases in the spine, high blood pressure, diabetes mellitus
Diabetes - threatening and incurable disease
, Depression (persistent depressed mood).
When using buserelin may experience the following side effects:
- the central nervous system: depression of mood (depression), which can often be replaced by agitation, sleep disturbances, headache;
- on the part of the endocrine system: decreased sexual desire, "tides" of the type of menopause, sweating, vaginal dryness
Vaginal dryness: Causes and Symptoms
Loss of bone calcium (osteoporosis phenomenon); during the first weeks of treatment may occur menstrualnopodobnye bleeding;
- an allergic reaction: hives, rash, redness and itching of the skin, angioedema;
- patients who use contact lenses may be signs of conjunctivitis; when using nasal drops and nasal spray can irritate the mucous membranes of the nasal cavity.
Buserelin - a drug that can not be used independently, only by a physician taking into account all the indications and contraindications.