Application

Diflucan - the commercial name of the drug fluconazole, each capsule contains Diflucan (depending on the form of) 50, 100, 150 and 200 mg of fluconazole. Packages 50 with a dosage of 100 mg and contains seven or twenty-eight capsules, but the capsule of 150-200 mg is only one box. Furthermore fluconazole capsule contains some additional neutral substance - lactose, corn starch, colloidal silicon dioxide, magnesium stearate, sodium lauryl sulfate. Diflucan is also available in a powder for suspension for oral administration in vials of 50 ml and a solution for intravenous infusion.

The properties of the drug Diflucan entirely due to the properties of fluconazole: it affects fungal cells, increasing the permeability of cell membranes, disturbing its growth and replication. At the same time, sufficiently gentle fluconazole acts on specific processes in the liver (in comparison with itraconazole, clotrimazole, econazole and ketoconazole). Fluconazole penetrates all body fluids. Fluconazole concentration in saliva and sputum are the same as its concentration in the blood plasma. The drug is completely excreted in the urine, about 80% - unchanged.

Application Diflucan

Diflucan is used in many diseases of a fungal nature. Plus, the drug - therapy can be started before the results of sowing and other laboratory tests.

• cryptococcosis;
• generalized candidiasis;
• candidiasis of the mucous membranes;
• Genital candidiasis;
• fungal infections of the skin;
• deep endemic mycoses.

The drug can be used in AIDS, cancer, especially for prevention with radiation and chemotherapy Chemotherapy - it always falls the hair? As well as to prevent frequent relapses when our favorite thrush. Diflucan can be used in children, however, only under medical supervision.

The daily dose in both children and adults, depending on the nature and severity of the fungal infection. Vaginal candidiasis Thrush - vaginal candidiasis: when to go to the doctor?   (thrush) in the majority of cases a single dose of the drug is effective. For infections requiring repeated administration of the antifungal drug treatment should be continued until the disappearance of clinical or laboratory signs of active fungal infection.

Taking the drug is independent of food intake. It is recommended to drink it with plenty of water and a few days refrain from drinking alcohol - to keep the liver. Research proven that the use of multiple drugs Fluconazole is unlikely to affect the efficacy of the combined oral contraceptive pill.

Contraindications

• Hypersensitivity to fluconazole or other azole compounds;
• concurrent use of terfenadine in patients receiving therapy with fluconazole Fluconazole - used with caution   400 mg / day or higher;
• co-administration of cisapride.

Portability of fluconazole is usually very good. If side effects occur, they are most often on the part of the gastrointestinal tract: nausea, abdominal pain Abdominal pain: Types and Symptoms , Diarrhea and flatulence. The second most common side effect after gastrointestinal disorders is rash. Sometimes the application of fluconazole is head bol.Izvestny rare cases of anaphylactic reactions, then the drug should be discontinued immediately. Experience with fluconazole indicates that the deterioration of driving ability and mechanisms associated with the drug, it is unlikely.

Diflucan and fljukostat Flucostat - do not take without medical supervision   - Is the trade name of the same drug - fluconazole. These drugs are manufactured by different pharmaceutical companies, but, in fact, no different, except for the price: Diflucan is produced by the French company Pfizer and is worth several times more expensive than domestic preparation fljukostat.

How does fluconazole

Fluconazole - is an effective antifungal drug broad spectrum. It inhibits the synthesis of certain vital substances in fungal cells, leading to their death. The sensitivity to fluconazole exhibit a kind of fungi Candida, the fungi that cause skin lesions (chromophytosis Ringworm - not only infectious disease , Epidermifitiyu foot, fungal nail and so on), as well as deep mycoses (microspores trichophytosis) and cryptococcosis.

Indications and contraindications for the use of Diflucan and fljukostat

Indications and contraindications for the appointment of Diflucan and fljukostat same. They are encouraged to nominate at various fungal infections caused by susceptible pathogens to fluconazole. It is recommended to use these drugs for prevention of fungal infections in immunosuppressed patients, such as cancer patients after chemotherapy or radiation therapy, or in patients with AIDS.

Contraindicated to use Diflucan and fljukostat if you are hypersensitive fluconazole and excipients included in the composition of these drugs, concomitant use of drugs that cause heart rhythm disturbances (eg, cisapride - a drug that increases the motility of the gastrointestinal tract and has the side effect of heart rhythm disorder ), pregnancy (except for life-threatening fungal infections), breast-feeding.

Be wary of these drugs used in human liver and kidneys, heart rhythm disturbances, along with drugs have toxic effects on the liver.

Diflucan fljukostat and well tolerated, but may cause side effects and the same. It is a headache, dizziness, cramps, nausea, vomiting, abdominal pain Abdominal pain: Types and Symptoms , Diarrhea, bloating, taste disturbances, liver dysfunction (including hepatitis Hepatitis - the scourge of our time   and necrosis of the liver), blood disorders (reduction in the number of white blood cells, platelets), allergic reactions, baldness, cardiac arrhythmia.

Formulations

French pharmaceutical company produces Fluconazole Pfizer under the trade name Diflucan capsules, as a powder for suspension or as a solution for intravenous administration. Capsules 50 mg manufactured by seven 100 mg - and two 150 mg - one capsule packaging. Powder for oral suspension is also available in different: 50 and 200 mg of fluconazole in 5 ml of the final suspension. Solution for intravenous administration is produced in bottles of 25, 50, 100 or 200 ml vials. 1 ml of a solution containing 2 mg of Diflucan fluconazole (0, 2% solution).

Domestic pharmaceutical company Pharmstandard released fluconazole under the trade name flukostat. A variety of dosage forms produced by this company at less than the company Pfizer. Capsules are produced by 50 mg (seven capsules per box) and 150 mg (1 capsule per package). Available as a solution for intravenous administration of 0.2% in vials of 50 ml of one piece in the package (1 ml of a solution containing 2 mg of fluconazole).

Other ingredients contained in the capsules Diflucan and fljukostat the same, there is only a slight difference in the composition of capsules.

Conclusion: The difference between diflyukanom fljukostat and is only that Diflucan capsules produced in a variety of dosage as well as a powder for suspension for oral administration. For the rest, these drugs are identical.

Prices

But the price of these drugs vary significantly. So, seven capsules of 50 mg Diflucan cost more than 800 rubles, while fljukostat in the same dosage form is less than 300 rubles. One capsule of 150 mg Diflucan costs about 400 rubles, the same capsule fljukostat - a little more than 150 rubles.

The difference is significant, though the preparations are identical and have the same effect on the body. Not the last role is played by advertising, as well as the active work of the representatives of Western pharmaceutical companies that promote their products on the Russian market, especially among doctors. So the choice of what kind of drug is available over the counter for the sick. A physician should explain to the patient, there is a difference between these drugs.

Galina Romanenko