Advantan - it is an external agent to reduce inflammation, swelling and itching. The main active ingredient of formulations Advantan contains synthetic adrenal hormones - glyukokortokoid nye means (GCS). This has both advantages (high efficiency) and defects (e.g., reduced cutaneous immunity).

How does advantan

Advantan produced in several dosage forms for external use - different kinds of ointments, lotions and emulsions. He developed the drug department Intendis German pharmaceutical company Bayer. The department is developing drugs to treat diseases of the skin, so when adventis is a very high-quality drug, in which all the side effects of corticosteroids appear minimal. General (systemic) effects on the body usually does not have adventan (except long-term use on large areas of skin).

The principle of operation Advantan is that it gets to the cells of all layers of the skin, is embedded in the DNA of cells and triggers a number of biological processes contributing to the rapid narrowing of the small blood vessels (capillaries) of the skin. This very quickly leads to the removal of edema, inflammation and itching of the skin.

Under what conditions apply

The ointment and cream advantan used for chronic inflammatory skin diseases. The most common cause of purpose Advantan are allergic and infectious-allergic skin disease. It is often used for atopic dermatitis in children - congenital allergic skin diseases that can move with age in atopic dermatitis. Advantan in this case are trying to use courses lasting less than a month - the duration of such a characteristic usually does not cause side effects for glucocorticosteroids.

Apply advantan and eczema (true, microbial, professional, seborrheic) in adults - a long flowing skin diseases in which advantan also applied courses lasting no more than three consecutive months. A special type of eczema - disgidrotichesky with dense blisters on the palms and soles also respond well to treatment Advantanom.

Apply the ointment and cream advantan well as simple contact and contact allergic dermatitis when the skin appears inflammation and swelling after contact with an irritant or a substance that causes the allergy.

Emulsion anvantan used to treat all these disorders, but in contrast to ointments and creams can be applied to more extensive areas of the skin without the threat of systemic action. Therefore Advantan emulsion is used to treat sunburn, exciting large skin surface.

Who should not primenenyat

Like any GCS advantan causes decreased immunity. Reduced skin immunity leads to the threat of joining the infection. Therefore, this drug should not be prescribed for tuberculosis skin TB skin - a rare form of the disease   and cutaneous manifestations of syphilis Cutaneous manifestations of syphilis - the main symptoms As well as in any viral skin infections - immunosuppression would lead to the rapid spread of these infections, such as herpes.

It does not apply advantan on skin affected by rosacea. Rosacea manifests itself as a red bumpy rash on the skin. The cause of this disease is the increased sensitivity of the small blood vessels of the face to various factors. One of these factors are corticosteroids.

Not applicable advantan well as hypersensitive to the components of the drug by the body of the patient, the age of four months and skin rashes on the background of different vaccines.

If advantan used in microbial eczema, caused by bacterial or fungal infection, is with him apply antibacterial or antifungal drugs.

Precautions any dosage forms Advantan used during pregnancy and breast- Breastfeeding - a personal choice   feeding while they are applied to the breast.

Side effects

Systemic exposure Advantan possible only with long-term use at high body surface area. With prolonged use can also skin changes such as the appearance of spider veins Spider veins - a sign of several diseases , White depigmented spots, stretch marks and so on. Immunosuppression may lead to skin infection connection.

Should not enter Advantan eyes - it will cause irritation. If the drug for a long time applied to the skin around the eyes, it can lead to the development of glaucoma - increased intraocular pressure.

Advantan - effective and safe enough medication. However, given that its main active ingredient has a hormonal origin, to the use of the drug should be approached with caution.

Galina Romanenko

Advantan - a drug for external use, the main active ingredient of which is a synthetic glucocorticoid hormone methylprednisolone atseponat. As with any drug of this series, it has contraindications for use.

Why has advantan Contraindications

Contraindications Advantan arise from the mechanism of action of this drug, which belongs to the glucocorticoid tools (GCS). Glucocorticoids - a hormone of the adrenal cortex that affect the carbohydrate and protein metabolism. The main side effects of high doses of corticosteroids are the delay in the body of water, swelling, excretion of potassium, increased decay of tissue proteins, increase in gastric acidity and the formation of stomach ulcers, diabetes, high blood pressure Blood pressure - dangerous if his swing? , Weight gain, increased body hair and so on.

But Advantan feature is that it has almost no overall impact on the body, as when applied topically absorbed into the blood, only a small part of the active substance. The main part of the active substance enters into cells of the skin and there activates a biological mechanisms, causing a rapid and significant narrowing of the small blood vessels. This causes that reduce inflammation, swelling, and itching associated with many skin diseases. But side effects in Advantan still there.

Side effects

The main side effect of this drug is to reduce the local immunity of the skin. Irritation and inflammation of the skin loses, thus protection against infection that long-term use of the drug is often attached to the underlying disease. Especially dangerous in this case the viral infection.

Another side effect of long-term use Advantan may be atrophy of the skin and the formation of her striae (stretch marks). This is because the SSC causes increased protein breakdown and inhibit the development of collagen, which is the basis of skin elasticity. Rupture of collagen fibers leads to the appearance of stretch marks on the skin.

Prolonged exposure to the small blood vessels sometimes leads to the formation of skin or mesh Stars from small blood vessels - telangiectasia, and the appearance of the white (lacking pigmentation) spots.

Long-term use can cause Advantan increased body hair and skin at the site of application. If advantan over time applied to the skin around the eyes, it can lead to an increase in intraocular pressure - glaucoma Glaucoma - a perspective possible blindness As well as irritation of the eyes in contact with her Advantan.

These side effects occur mainly Advantan with prolonged use at high doses. If you apply advantan short courses, the side effects usually do not happen. However, the manufacturer Advantan (German pharmaceutical company Bayer) has established a number of contraindications to the use of this drug.

Contraindications for use

Advantan should not be prescribed for specific infectious processes accompanied by skin manifestations - skin tuberculosis TB skin - a rare form of the disease   and syphilitic rashes on the skin. Application Advantan in this case will facilitate the spread of the infection. When a non-specific bacterial or fungal skin infection, if you want to reduce the inflammation, swelling, itching and pain, it is recommended to use advantan with antibacterial and antifungal agents.

It is very dangerous to use any of GCS, including Advantan, viral infections - reduced immunity contributes to the rapid proliferation and spread of the virus. Therefore advantan contraindicated in herpes infection, herpes zoster, chickenpox, and so on.

Since advantan has a marked effect on the small blood vessels of the skin, it can not be used in rosacea - it is a provoking factor for exacerbation of skin disease.

It is also impossible to apply advantan are hypersensitive to its components the body of the patient, the age of four months and the appearance of the skin rash after the administration of any vaccine.

With caution and only after weighing all the pros and cons advantan administered during pregnancy and nursing Breastfeeding - a personal choice   feeding. It is not recommended to apply advantan in any dosage form in the mammary gland.

Advantan non-toxic drug, and a single application, even in a large area of ​​skin it does not give any side effects and intoxication. Side effects occur only at long-term use of the drug. Treatment of these side effects is to remove the drug.

Galina Romanenko