Vasculitis - is inflammation of the walls of blood vessels infectious and allergic or autoimmune (allergic to the patient's own tissue) character. Such processes take place for a long time, and if they do not start on time properly treated, will sooner or later lead to serious violations on the part of various organs and tissues.

The consequences of vasculitis - why they depend

Different types of vasculitis occur in different ways, and the effects they may be different. In addition, the consequences of vasculitis depend on many other things: the age and the individual characteristics of the patient, the presence of his other chronic diseases, forms of the disease and so on.

But the biggest impact on the consequences of vasculitis provide timely detect it and immediately appointed an adequate treatment. Today, there are modern methods of treatment of such patients, which allows to suppress the inflammatory process and constantly maintain a state of remission.

But with common regimens all physicians agree that the approach to the treatment of each patient must be individualized vasculitis. It is important to establish the correct diagnosis time also because the primary or systemic vasculitis and secondary (developing against the background of some other diseases) are treated differently.

Unfortunately, the diagnosis of vasculitis is now not up to par, the disease is often detected at an advanced stage already. But at this point many of vasculitis can still be treated successfully with the subsequent recovery of the function of internal organs, in which the changes occurred. But should not deceive ourselves: vasculitis - a serious illness, which may well lead to the death of the patient. Effects of different species of systemic vasculitis may be different.

The effects which may occur in hemorrhagic vasculitis

When hemorrhagic vasculitis Hemorrhagic vasculitis - a rare disease   lesion occurs small vessels in the skin, joints, gastrointestinal tract and kidneys. The skin lesions presented hemorrhagic rash (bleeding), which passes without any consequences after 4-8 weeks after the onset of the disease. Also completely campaigns and joint damage, but the lesions of the gastrointestinal (GI) tract and the kidneys can have significant consequences.

Thus, the defeat of the small blood vessels of the GI tract can lead to perforation of the intestinal wall, intestinal bleeding and peritonitis. Today, a hemorrhagic vasculitis Vasculitis - when blood vessels refuse to work   - Is one of the most studied species of systemic vasculitis, intestinal learned to fight its manifestations, which significantly reduced the mortality from this disease.

The defeat of the small blood vessels of the kidneys manifested as symptoms of glomerulonephritis and develops later than other symptoms. Feature glomerulonephritis in this disease is that it often runs completely asymptomatic and does not bother the patient. This is very dangerous, because at the same time steadily declining kidney function, which is then restored it will be impossible - develop chronic renal failure (CRF) patients and can not exist without hemodialysis Hemodialysis: artificial kidney   - Blood purification using special equipment.

The consequences that may arise in periarteritis nodosa

This disease often develops in the presence of hepatitis B. It affects the arteries of medium and small caliber to the formation of many small aneurysms (extensions) and stenosis (narrowing) of blood vessels that feed the skin, muscles and internal organs. This leads to thrombosis Thrombosis - the cause of heart attack and stroke   vascular and circulatory disorders of various organs.

The illness is very serious, with fever, weight loss up to complete exhaustion, severe pains in muscles and joints, the appearance of a hemorrhagic rash and rash in the form of subcutaneous nodules, neuritis violation sensitivity or severe pain in the limbs. Violated movement in the limbs: patients walk with difficulty, can not dress themselves, and so on. Recovering from such neuritis is very slow, and often are the consequences in the form of gait disorders of the type "horse foot" with sagging of the foot by bending your knees.

It can cause severe consequences shock syndrome: circulatory disorders of the intestinal wall can cause necrosis and perforation followed by peritonitis.

Consequences can be severe kidney damage. Is glomerulonephritis leads to resistant hypertension (high blood pressure), which, in turn, is fraught with complications on the part of the brain (stroke) and heart (myocardial infarction). After a few years usually develop chronic kidney failure, which can lead to death of the patient.

Effects of vasculitis depends on many factors. The main objective of this disease is its early detection and proper treatment, then, perhaps, cost and without serious consequences.

Galina Romanenko

Nimesil most often used for pain. This can be joint pain Joint pain - how to understand what is going on? In the spine, in the ear, toothache or pain during menstruation. In all these cases nemisil bring relief to the patient. It is also a new generation of drug that does not cause stomach irritation.

Nimesil refers to a group of non-steroidal anti-inflammatory drugs (NSAIDs) which have analgesic, antipyretic and anti-inflammatory properties. The name of this group received the drug because of its anti-inflammatory effects, they are similar to steroid hormonal drugs, but as a typical steroid structure they do not, they became known as non-steroidal anti-inflammatory drugs.

Origin nimesil

First of NSAIDs is considered to acetylsalicylic acid, which was opened more than a hundred years ago. After that, there was still plenty of drugs in this group, some of them better relieves inflammation and pain, while others were used as a fever-reducing medicine. But all NSAIDs early period there was one major drawback: they greatly irritate the stomach lining. And since they take in some diseases accounted for a very long time, the patients developed gastric ulcer and duodenal ulcer.

But the pharmaceutical industry has coped with this task. It was found that in humans there is the enzyme cyclooxygenase (COX), which is divided into two types: COX-I and COX-II. The main function of COX I - protection of the mucosa of the gastrointestinal tract, and COX-II - the development of inflammatory reactions. Nonsteroidal anti-inflammatory drugs inhibit the action of COX as a whole, and at first could not manage to create a drug that inhibits the activity would only COX II.

Yet such a drug was able to do, he has gained international name nimesulide. Today is available for several different preparations of NSAIDs, can inhibit only COX II. The German pharmaceutical company Berlin-Chemie produces nimesulide under its own name nimesil.

Application nimesil

Nimesil used as an analgesic and anti-inflammatory agent mainly in various diseases of the joints and spine. It is used in such cases is very long, sometimes for life, so it is important that the drug had as little as possible side effects. Unfortunately, completely separate the effect on COX-I and COX-II failed, yet the two parts of the same enzyme. Therefore, some irritation of the gastric mucosa with prolonged use is still present. Nemisil also has a toxic effect on the liver, so it is not recommended for use with other hepatotoxic drugs, and alcohol.

As nimesil anesthetic used in dental pain, ear pain, painful menstruation, pain from injuries and bruises, in the postoperative period after various operations.

Available nimesil in paper bags, which is not powder and fine granules. Accept it after a meal, dissolving in half a glass of water.

Contraindications nimesil

The main contraindications for receiving nimesil are serious diseases of internal organs (especially the cardiovascular system, kidney, liver), bleeding tendency, including the reduction of blood clotting, allergic reactions and the idiosyncrasy of other drugs NSAIDs, peptic ulcer and duodenal ulcers, ulcerative processes in the gut, alcoholism, drug addiction and substance abuse Substance abuse - as a child back to life? , Children under twelve years of age, pregnancy and breastfeeding.

Side effects nimesil not too pronounced and occur rarely. The main side effects are detrimental effect on hematopoiesis (reducing the number of erythrocytes, platelets and increase the number of eosinophils) - this may lead to anemia, bleeding and allergic mood of the organism. Allergic reactions are rare, but can be from mild (slight skin rash), and severe (anaphylactic shock). Sometimes nimesil can cause disruption of the central nervous system, which is manifested by drowsiness, headaches, constant anxiety, headache. There may also be palpitations and high blood pressure.

From the side of gastrointestinal side effects are also rare, but nevertheless there is nausea, vomiting, diarrhea or constipation, bloating, abdominal pain Abdominal pain: Types and Symptoms , Very rarely - gastrointestinal bleeding ulcer in the stomach or intestines, liver toxicity and kidney. Sometimes, while taking nimesil noted the appearance of a lower body temperature Lowered body temperature - or the rate of disease?   and weakness.

Nimesil - quality analgesic and anti-inflammatory drug.

Galina Romanenko