Derinat - a drug that restores the immune system, improves the regenerative processes in the tissues and the formation of blood cells. How it is applied topically to treat a variety of wounds, burns, diseases of the skin and mucous membranes, and in the form of injections for the treatment of internal diseases.

The mechanism of action derinata

Derinat (active ingredient - sodium deoxyribonucleat) - is an immunomodulator (means restoring the immune system), which is produced by the Russian pharmaceutical company ZAO FP Tehnomedservis in the form of injection solutions in ampoules for external use in vials for topical application in flakonah-. This drug has a natural origin, it is prepared on the basis of sturgeon roe, highlighting one highly purified sodium salt of DNA.

As an immunomodulator derinat stimulates the immune system against all infectious agents (bacterial, viral and fungal), increasing the body's resistance to infections. Immunomodulatory mechanism of action is that derinat activate lymphocytes responsible, both cellular and humoral immunity for.

In intramuscular derinat enhances cell-mediated immunity against many pathogens including Chlamydia Chlamydia: insidious and widespread disease , Staphylococcus aureus, Escherichia coli, Helicobacter pylori (the organism causing gastric ulcer and duodenal ulcer). Derinat anti-inflammatory effect and helps to restore the operation of the lymphatic system, particularly in the inflammation, cleansing the body from toxic products of inflammation and tissue breakdown.

Derinat for tissue repair

Derinat promotes tissue regeneration, both in the skin and mucous membranes (wounds, burns, trophic ulcers) and in various inflammatory and ulcerative necrotic processes in internal organs.

Thus, when necrotic processes (they are accompanied by tissue death) under the influence of derinata tissue in which there was necrosis, quickly rejected that contributes to their faster recovery. Under the influence of derinata rapidly cleared and heal infected wounds, severe burns, it protects tissues from radiation exposure.

Derinat intramuscular injection is used in the treatment of diseases such as coronary heart disease. After treatment derinatom increased exercise tolerance, reduced the number and duration of angina attacks Angina: When the heart needs help .

Improved under the influence of derinata for gastric ulcer and duodenal ulcer - scar ulcers, decreases the inflammatory process is suppressed vital functions of the infectious agent.

Derinat stimulates production of white blood cells responsible for cellular and humoral immunity - granular leukocytes and lymphocytes, and also reduces the sensitivity of these cells to the damaging effects of chemotherapy and radiotherapy in the treatment of cancer.

Based on laboratory studies, it was found that derinat not carcinogenic and has no negative impact on the child during the prenatal period.

After intramuscular administration derinat rapidly absorbed into the blood and is distributed in organs and tissues. It is found in all organs and tissues, including the central nervous system by activating them in metabolic processes. The largest concentration of the drug found in the lymph nodes, bone marrow, spleen and thymus - bodies responsible for immunity. Derinat partially destroyed in the liver but is mainly excreted unchanged by the kidneys and intestines.

Indications and contraindications for use derinata

Solutions for outdoor applications prescribe:

• for the treatment and prevention of infections of the upper respiratory tract and internal organs - acute respiratory viral infections, sinusitis - a topical solution is instilled into the nose;
• when nonhealing wounds, burns, frostbite, trophic ulcers, bedsores - in the form of applications solution for topical application;
• for any damage to mucous membranes (eyes, mouth, nose, vagina, rectum) - in the form of a rinse, wash, applications and solutions for topical application.

Derinata solution for injection administered:

• cancer patients after chemotherapy and radiotherapy, as well as radiation damage;
• in severe chronic inflammatory processes in all organs and tissues;
• gastric ulcer and duodenal ulcers, as well as any erosive and ulcerative processes in the gastrointestinal tract;
• coronary heart disease and cardiovascular disease;
• when occlusive disease (zapustevanii arteries) of the lower extremities;
• chronic gynecological and urological diseases caused by chronic infections, which often lead to infertility and impotence Impotence - a female perspective on the problem ;
• chronic bronchitis and pneumonia;
• rheumatoid arthritis;
• pulmonary tuberculosis;
• before and after various operations are for prevention of septic complications.

Derinat for external use is contraindicated only if you are hypersensitive to the drug. Derinat for intramuscular injection is contraindicated during pregnancy and nursing Breastfeeding - a personal choice   feeding.

Side effects that may occur when applying derinata

For external use derinata adverse effects were observed (except for allergies). In intramuscular derinata may appear a little soreness at the injection site, short-term fever (temperature can rise to 38 ° C and a half - three hours after administration derinata) and reduce blood sugar. Allergic reactions are also possible.

Galina Romanenko

Infectious mononucleosis - a disease caused by a virus, Epstein-Barr virus or human herpesvirus type 4. It is most common in teenagers, but it can hurt people of any age. Due to the fact that mononucleosis is transmitted through the saliva, it is sometimes also called the "kissing disease."

Causes of infectious mononucleosis

The cause of this disease is Epstein-Barr virus. According to scientists, the virus infected more than 98% of the world population, the vast majority of people are native speakers, have not yet reached the age of 30 years. A significant part of the virus infection does not cause any symptoms.

Most often the disease develops in people aged 15 to 17 years. Infectious mononucleosis in children under two years of relatively rare.

Epstein-Barr virus is transmitted by airborne droplets. Infection can occur, for example when an infected person coughs or sneezes using the same dishes with healthy people, or kissing them. Infection can also occur through blood and semen.

It is believed that Epstein - Barr virus lives on various objects, which gets the saliva of an infected person (such as toothbrushes or glasses) as long as they remain moist. While there is no evidence that disinfection helps prevent the spread of the virus, so to prevent this, the patient must use separate utensils to store your toothbrush separate from the others, and so on.

In the first weeks after infection a person can spread it for several weeks, even before they have any symptoms. Regardless of the cause Epstein - Barr virus mononucleosis, or not, it remains in the body in a latent state. If one day the virus is reactivated, people will once again be contagious to others.

Risk groups for the development of infectious mononucleosis include people aged 15 to 25 years, students (especially those who live in dormitories), nurses, employees of kindergartens, people with weakened immune systems.

Symptoms of infectious mononucleosis

According to studies, the symptoms of infectious mononucleosis in adults Mononucleosis in adults - a rare phenomenon   It appears only in 35-50% of cases of infection with the Epstein - Barr virus. In children, the virus leads to a pronounced signs of disease even rarer. The most common symptoms of mononucleosis Symptoms of mononucleosis - easy to make a mistake :

• Drowsiness;
• Heat;
• Malaise;
• Lack of appetite;
• Muscle aches;
• Skin rash;
• A sore throat;
• Swollen lymph nodes;
• Enlargement of the spleen;
• The increase in the liver;
• Lethargy;
• Fatigue.

Symptoms of infectious mononucleosis in children Mononucleosis in children - possible complications   They tend to be less severe than in adults. In many cases, the disease causes only brief discomfort that parents take for the common cold.

In rare cases, infectious mononucleosis may experience the following symptoms:

• Chest pain;
• Cough;
• Headache;
• Hives;
• Jaundice;
• Nosebleeds;
• Increased heart rate;
• Increased sensitivity to light;
• Shortness of breath.

When you see these symptoms, patients are advised as soon as possible to contact your doctor.

Typically, patients recover mononucleosis 2-4 weeks (although the virus, as already mentioned, remains in the body), but some patients as early as a few weeks or even months may experience unusual weakness and constant fatigue.

Diagnosis of infectious mononucleosis

For the diagnosis of this disease is usually carried out blood tests, during which identifies antibodies (immunoglobulins) to Epstein - Barr virus. IgM type antibody detected only during the active phase of infectious mononucleosis. IgG antibody blood test can identify later, when the patient begins to recover.

Results of analyzes for infectious mononucleosis may simply be positive or negative (the presence or absence of antigens, respectively). They may also be presented in the credits - a conditional value which shows the concentration of antibodies to viruses, bacteria or other pathogens (in the case of mononucleosis - to Epstein - Barr virus) in the material which was analyzed. His talk more precisely, the caption - an indicator of how much you need to dilute the sample, so that it was impossible to detect antibodies. For example, a titer of 1: 8 indicates that the antibodies can be detected when one of the blood diluted by eight portions of brine, but they are not detected when the solution was prepared at a ratio of blood to one part of the solution is sixteen. The larger second number, the higher the concentration of antibodies in the sample.

Blood picture in infectious mononucleosis is usually as follows:

• The level of white blood cells increased slightly, and reaches a peak in the second or third week of the disease;
• Approximately 40% of patients elevated levels of bilirubin in the blood (although jaundice only 5% of patients with mononucleosis);
• The titer of greater than 1: 320 - reliable indicator of active infectious mononucleosis. (Titer more than 1:10, but less than 1: 320 means that the patient is infected with Epstein-Barr virus, but it does not have active mononucleosis, and the titer of at least 1:10 happens to people who are not infected with the virus).

It should be noted that if a person has been infected only a few weeks ago, a blood test for antibodies to the Epstein-Barr virus may give a false-negative result. If the analysis showed the presence of antibodies, but the patient has symptoms associated with mononucleosis, after a time, the analysis need to be repeated. In a patient with very weakened immune systems analysis mononucleosis Analysis for mononucleosis - assistance in diagnosing   sometimes it fails.