One modern antifungals broad spectrum is orungal. Analogs orungala incorporate as active principle itrokonazol. But is it a drug orgiginalnym orungal.

Which counterparts have orungala

Active ingredient orungala (manufacturer - the pharmaceutical company Janssen Pharmaceutica, Belgium) is itraconazole. Orungal is the original drug. In addition, it produces a number of generic orungala - antifungal drugs in the same composition. Itraconazole is active substance following medications: Irunine Irunine - the enemy of Candida , Itrazola, itramikola, kanazola, mikonihola, itraconazole-ratiopharm, itraconazole, kanditrala, orungamina, orunita, rumikoza.

The generic drugs differ from the original product? The difference can be as a starting material from which the drug, including the percentage of impurities contained in it. In addition, some differences may be in the technology of drugs, although modern, globally accepted technology of drug GMP implies a common approach to the material and technical base, equipment, technologies used and the training of personnel of pharmaceutical companies.

Orungal analogues of Russian production

Generics orgunala Russian production are Irunine, itrazol, itraconazole, orungamin, Orun, rumikoz.

Irunine (Veropharm, Russia) is available in capsules for oral administration of 100 mg and vaginal tablets. Irunine capsules is an analog orungala, differing from the latter only by the composition of excipients. It is used internally for various fungal diseases, including the systemic mycoses. In the form of vaginal tablets Irunine apply at thrush - Vulvovaginal candidiasis Vulvovaginitis - a disease of children and the elderly .

Intrazol (Vertex, Russia) and itraconazole (Biocom, Russia) orungamin (Ozon, Russia), Orun (FP Obolensky, Russia), rumikoz (Valenta Pharmaceuticals, Russia), itramikol (Moskhimpreparaty them. Semashko, Russia), mikonihol (ABBA RUS , Russia) are produced in capsules for oral administration 100 mg, differ from the original drug composition only excipients. Indications, Contraindications, side effects of generic these are exactly the same as the original drug orungala.

Orungal analogues of Indian origin

Itraconazole is active substance as Indian-made generic drugs - itraconazole-ratiopharm (Ratiopharm, India) and kanditrala (Glenmark Pharmaceuticals, India). Both drugs are available in capsules and have the same indications, contraindications and side effects that orungal.

What are the characteristics of action counterparts orungala

The effect of all analogs orungala due to the suppression of synthesis of ergosterol, a component of fungal cell membranes, which leads to destruction of these cells. All of these drugs are well absorbed from the gastrointestinal tract into the blood comes first and then the fabric. In the skin, the nails of these preparations in a concentration several times higher than in blood. Large concentrations orungala analogues are also contained in the internal organs, which allows their use for the treatment of systemic fungal infections.

Virtually all of the most common fungal infections are treated using orungala insensitive thereto only isolated pathogens fungal infections including tropical.

We can not always take itraconazole if you are hypersensitive to drugs during pregnancy, infant feeding Breastfeeding - a personal choice   and feeding simultaneously with drugs, which are the same as itraconazole, destroyed in the liver using the same enzyme CYP3A4. Be wary of these drugs are prescribed for violations of the cardiovascular system. Liver and kidneys.

Because of the side effects of itraconazole known negative inotropic effect - reduction in force of contraction of heart muscle. Patients who have already had heart problems, may develop heart failure as tekov and shortness of breath.

On the part of the gastrointestinal tract upon receipt of all analogues orungala Orungal - antifungal broad spectrum   may cause nausea, vomiting, abdominal pain, and sometimes - liver dysfunction. From the nervous system can occur headaches, dizziness, pain in the course of the peripheral nerves. Women may have menstrual irregularities. There are also a variety of allergic reactions.

Action analogues orungala is no different from the action of the original drug.

Galina Romanenko

Meningococcal disease is rare, but it is very dangerous, so be aware of its symptoms should all parents. The disease is in children and adults, but especially difficult runs under the age of ten years.

Activators of meningococcal infection

Infectious agents are the three serovar Neisseria meningitidis: A, B and C. They die quickly in the environment. Infection occurs through airborne droplets by direct contact with an infected person. Bacteria penetrate the mucosal tissues of the nasopharynx and multiply there.

From the resistance of the organism, which hit pathogens it depends on whether a person is sick and what kind of form. Individuals with good immunity Immunity - types and characteristics in children in adults   do not become ill, and are short-term carriers of the infection. That they are the main sources of infection.

Types of meningococcal infection

Meningococcal disease can occur in three ways: meningococcal nasopharyngitis, meningococcemia and meningococcal meningoencephalitis.

• Meningococcal nasopharyngitis is no different from the usual nasopharyngitis and found only bacteriologically.
• Meningococcal meningoencephalitis - a serious disease affecting tissues and membranes of the brain.
• Meningococcemia - meningococcal sepsis - a very serious disease, for which primarily affected vessels, both surface and internal organs. Due to this there is a severe infectious-toxic shock. A characteristic feature is menigokokkemii rash.

Clinical manifestations of meningococcemia

The disease begins suddenly - the body temperature rises, the child becomes sluggish, it may be a little runny nose and sore throat phenomenon Pharyngitis - recommended home treatment . Noteworthy is marked pallor of the skin, especially the face. Eight - Twelve hours on a temperature increase rash appears pale pink in color, which is often regarded as allergic.

If at this time to see a doctor, he will appoint the treatment of respiratory viral infections and allergy medications adds. Parents of young children can be offered hospitalization due to the severity of the general condition.

Against the background of the treatment, the child's state of health is still much worse. The body temperature is kept at high numbers, lethargy and weakness increase. A rash on the skin is transformed, in its place there is another, very characteristic for meningococcemia. It is usually described as a hemorrhagic rash, with elements of central necrosis, irregular, star-shaped, asymmetrical. Number of Cells from one to several dozen. The size is usually from a point to a few centimeters.

When a star-shaped rash meningococcemia diagnosis is not difficult.

Treatment of meningococcemia

The patient was urgently hospitalized in a separate box profile infectious hospital. Treatment should be started immediately, was the first physician to detect the disease. Even at home, and chloramphenicol corticosteroids administered in the required dosage, intramuscularly.

The treatment lasts at least two weeks, depending on the severity of the disease. First of all, there is a struggle with infectious-toxic shock. That is why many antibiotics Antibiotics - whether they will help you in the foreseeable future? That have antibacterial properties, does not apply to treatment - the toxins are released from the killed bacteria, increase toxicity, worsening the patient's condition. Apply bacteriostatic antibiotics focus primarily chloramphenicol.

Eruptions from the skin gradually disappear - at first small, then larger ones. Large necrotic and may even heal scarring.

After discharge from the hospital the child for two years have seen a neurologist.

Svetlana Shimkovich