Because of the high nervous and mental stress and information we need today, especially medicines that improve the functioning of the brain. It relates to such drugs meksidol, which is used in many diseases of the central nervous system, improves blood flow to the brain and its metabolism in tissues.

The mechanism of action mexidol

Mexidol primarily an antioxidant Antioxidants: the truth about the notorious benefits That is, it eliminates the free radicals which are separated during biochemical reactions and destroy the cells of the brain. As a result, it is improving all the metabolic processes in cells, and most importantly - the state of cell membranes through which the necessary cells and removes waste substances. Restore not only the membrane of nerve cells, but also the membrane of myocardial cells, erythrocytes, platelets.

Mexidol and energy metabolism in cells

Mexidol improves energy metabolism in the cells, causing the cells become more resistant to various external influences, they are not so easily destroyed, and the effects of stress (adaptagennoe and anti-stress effect). Good energy metabolism and promotes the fact that fewer cells need oxygen and thus may exist in relatively normal conditions of deficiency (antihypoxic effect). This is very important in acute and chronic circulatory disorders of the brain, when, due to narrowing of blood vessels to the nerve cells not getting enough blood, and therefore oxygen. Under normal conditions, an acute shortage of ischemic stroke ends, that is the withering away of brain tissue, but mexidol can prevent this process.

Mexidol and cholesterol metabolism

The positive impact has mexidol and cholesterol metabolism: under its influence decreases in the number of blood total cholesterol and "bad", which is deposited in the blood vessels as atherosclerotic plaques. Under the influence of mexidol atherosclerotic process can go back, that it will certainly have a positive impact not only on the state of the brain, but also on the condition of blood vessels, and hence the whole body (anti-sclerotic effect).

Mexidol and vessels

It is very important mexidol effect on the blood vessels, especially smaller ones. They improve blood flow. Blood does not stagnate and even because of its improved rheological qualities - flowability and inhibited platelet aggregation (bonding), whereby is prevented the formation of thrombi. This quality helps with varicose veins Varicose veins - the operation is inevitable?   and hemorrhoids Hemorrhoids - a shameful disease In which there is a tendency to thrombosis (angioprotective action).

As a result of the positive impact mexidol on metabolism and blood flow to the brain is improved and higher functions - the ability to learn, memory, concentration (nootropic effect).

Mexidol widely used in drug treatment practice. It is used for poisoning by alcohol and any substance. However, he does not aggravate intoxication and poisoning, but rather sobering. When abstitentnom syndrome (hangover) miksedol removes the unpleasant symptoms of the central nervous system and the autonomic nervous system, which significantly improves the overall health of patients.

The agent has a protective effect at high radiation: it protects cells from the effects of radiation by improving metabolism and stabilize cell membranes.

Application mexidol

It is used and in severe septic diseases of the abdominal cavity, during which affected the status of all organs and tissues, and especially of the abdominal cavity. Such diseases include severe acute pancreatitis, pancreatic necrosis (death of tissue of the pancreas) and peritonitis (inflammation of the peritoneum - the thin membrane covering the inside of the entire abdominal cavity). In this case, improving blood circulation and metabolic processes in the pathological focus can be a decisive factor that will save the lives and health of the patient.

Mexidol Vosloo intake of rapidly enters the bloodstream, it is carried on a cloth and then decomposed in the liver and in the form of metabolites (products of metabolism) output through the kidneys. This turn mexidol body needs to maintain good liver function and kidney function. This drug has few contraindications, but the main one is it normal renal and hepatic function.

Mexidol not recommended during pregnancy and nursing Breastfeeding - a personal choice   breast, but it is due to the fact that clinical research on these groups of patients producers were not carried out.

Domestic drug mexidol is a good tool in the treatment of many diseases.

Galina Romanenko

  In some diseases, a strong muscle spasm can cause harm. To remove a spasm (which, incidentally, relieve the pain in the area), produced special drugs - muscle relaxants. One of these drugs is Mydocalmum manufactured Hungarian pharmaceutical company Gedeon Richter.

The mechanism of action Mydocalm

Mydocalm (tolperisone hydrochloride) - a centrally acting muscle relaxant, which is available in tablets and oral solution for injection in vials. The mechanism of action of the drug is that it slows nerve impulses behavior twigs on sensory nerves, and also blocks carrying motor impulses in nerve cells. That is, information from skeletal muscle enters the central nervous system (CNS) is limited, moreover, the response is blocked and CNS.

Furthermore, Mydocalmum inhibits the release of neurotransmitter (substance by nerve impulses which are transmitted along the nerve fibers, such as adrenaline) by inhibiting the flow of calcium ions in the synapses (space transition processes one nerve cell to another) - namely calcium ions promote release of neurotransmitters. Since it relieves spasms of skeletal muscles that squeezes blood vessels and improves peripheral circulation. This effect is further reinforced by the fact that the locking release of adrenaline into the blood (it causes a spasm of blood vessels).

Mydocalm also has a local anesthetic effect, but it does not affect the cortex of the brain and causes of phenomena such as lethargy and drowsiness.

If ingestion Mydocalmum Mydocalm: drug from muscle spasms   is well absorbed in the gastrointestinal tract and rapidly (half an hour) into the blood, and thence into the muscle begins to operate. O Mydocalmum starts after half an hour, pre-decomposing in the liver and kidneys to metabolites (products of metabolism). Write mainly in the urine without affecting the state of the liver and kidneys, even with repeated repetition of the course of treatment.

Indications and contraindications for use Mydocalm

Indications for use Mydocalm are:

• persistent increase tone and spasms of skeletal muscles, arising on a background of organic diseases and trauma of the central nervous system (eg, multiple sclerosis, consequences of stroke Stroke - consequences: recovery and treatment , Encephalomyelitis, spastic paralysis);
• persistent increase tone and spasms of skeletal muscles against various diseases of the musculoskeletal system (for example, diseases of the spine and large joints);
• condition after orthopedic and trauma operations;
• in violation of the innervation of the peripheral blood vessels, which can lead to persistent spasms and circulatory problems in this area (for example, occlusive disease, vascular lesions in diabetes mellitus).

Contraindications for use Mydocalm are:

• persistent muscle relaxation - myasthenia gravis Myasthenia gravis - not to be confused with chronic fatigue ;
• Children under one year;
• idiosyncrasy Mydocalm.

Relative contraindication is pregnancy, especially during the first twelve weeks and the period of feeding the child Breastfeeding - a personal choice   feeding. In this case, the reference point is the status of women, the decision to appoint the drug is taken after studying the ratio of the expected therapeutic effect and the possible risk to the fetus or child.

Mydocalm no effect on coordination, ability to concentrate attention and speed of psychomotor reactions, so driving and any other work associated with increased risk to life and health when it is received is not contraindicated.

Side effects when using the drug and overdoses

In applying Mydocalm may experience the following side effects:

• from the gastrointestinal truck: nausea, vomiting, abdominal discomfort;
• the central nervous system: muscle weakness, headache;
• the part of the circulatory system: decrease in blood pressure;
• Various delayed allergic reactions (itchy rash) and immediate (urticaria, angioedema, anaphylactic shock) type.

Data on overdose Mydocalm not. The drug can be used in combination with other drugs, including sedative and hypnotics, and preparations containing alcohol.

Mydocalm - a drug, which basically assigns neurologist independently take such drugs, despite the fact that they give little side effects, in no case can it may cause disorders of many organs and systems.

Galina Romanenko