Acyclovir - is an antiviral drug that has no toxic effects on the body, and hence does not have a large number of contraindications. Acyclovir is not contraindicated even during pregnancy (he was appointed, but with caution), and this is saying a lot.
Why Acyclovir has few contraindications
This follows from its mechanism of action: acyclovir
Acyclovir - as it is safe?
It penetrates only in cells infected with the virus to healthy cells it exerts no action. This happens because the virus infected cells begin to secrete an enzyme that converts acyclovir into an active state, and allows it to penetrate into the cells, overcoming the protection of the membrane. In infected cells, virus replication occurs, acyclovir blocking this process.
Show sensitivity to acyclovir herpes virus type I and II, causing herpetic lesion of the skin of the lips and body, as well as genital herpes. In addition, chuvstvtielen acyclovir herpes virus that causes chickenpox and shingles
Shingles and chickenpox - from the same pathogen
And also (in lesser extent) cytomegalovirus
Cytomegalovirus - what is its danger?
Acyclovir is available in tablets (200, 400, 800 mg) in dry matter in vials for solution for injection, in the form of ointments, ophthalmic ointments and creams. Most side effects caused by administration of acyclovir intravenously, is considered the safest use of acyclovir dosage forms for topical and local application.
What are the possible side effects of the treatment with acyclovir
Acyclovir - a non-toxic drug, it gives little side effects, nonetheless, they have before administration of the drug and the doctor to tell them to a patient.
When the pill inside may cause nausea, vomiting, diarrhea, abdominal pain, various skin rashes, headaches, dizziness, sleep disturbances, decreased performance and concentration, hallucinations, hair loss, transient disorders of the liver and kidneys (seen in changing the laboratory), reduction in the number of blood leukocytes and erythrocytes.
When administered intravenously acyclovir side effects other than those described may develop severe complications from the kidney - acute renal failure due to the fact that renal tissue salt crystals are deposited. There are also serious side effects in the central nervous system in the form of excitation, which is replaced by sleepiness, hallucinations, seizures. If the patient in time will not be helped, he may plunge into a coma. At the site of injection of acyclovir may develop inflammatory processes, including the walls of the vein (phlebitis).
The local application of 3% ophthalmic ointment may cause itching and burning in the eyes, superficial inflammation in the cornea, conjunctiva and eyelid margins. For external use ointment 5% and 5% cream in place of their application may cause itching, burning, dryness, peeling, skin rash, mucosal redness and swelling.
Who should not take acyclovir
Contraindications acyclovir only two: individual intolerance of the drug and breast-feeding
Breastfeeding - a personal choice
breast - acyclovir is excreted in breast milk.
With caution and in lower doses should be prescribed acyclovir with severe kidney disease in violation of their function as deposition in renal tissue salt crystals can cause even greater aggravation of the problem. In order to reduce the deposition of salt crystals in the kidneys, the patient should drink more. With extreme caution should be used in such patients, intravenous administration of the drug, as it is fraught with the development of acute renal failure. During the course of treatment with acyclovir should monitor kidney function by means of laboratory tests.
During pregnancy acyclovir is prescribed, but with caution, only if the expected benefit to the mother's body than the potential risk to the body of the child. But in practice, it sets the safety of acyclovir for pregnant women and the fetus. Of course, all must be treated under the supervision of a physician and under laboratory control as acyclovir can cause renal dysfunction, liver and changes in the mother's blood, and pass through the placenta to the fetus.
Precautions Acyclovir appointed the elderly and patients with impaired liver function, they may also be administered smaller doses of the drug. By carefully following the indications and contraindications also require those with mental and neurological disorders, dehydration of any origin, cardiovascular failure.
Acyclovir has few contraindications, but treatment with this drug must be conducted under the supervision of a physician.