Aspirin (acetylsalicylic acid) belongs to the group of drugs known as salicylates. The action of aspirin is based on reducing the amount of substances in the body, which causes pain, inflammation and fever. Aspirin is used to treat mild to moderate pain, as well as lowering the temperature or reduce inflammation. In some cases, the use of aspirin to treat or prevent heart attacks, stroke Stroke - a serious brain injury   and angina. But for the treatment of cardiovascular diseases aspirin can be taken only under medical supervision.

Important information about aspirin

Aspirin is not recommended for children and adolescents to reduce the temperature, especially if the child has flu symptoms or chicken pox. When using aspirin on a background of acute viral diseases (influenza, parainfluenza, chickenpox) in children can cause serious liver damage - Reye's syndrome, which can even lead to death.

Stop taking aspirin and call your doctor if you find yourself signs of bleeding in the stomach or intestines. These characteristics include: black, tarry stools mixed with blood, coughing up blood or vomit that looks like coffee grounds.

Do not drink alcohol during treatment with aspirin. Alcohol may increase your risk of stomach bleeding.

Aspirin is sometimes used to treat or prevent heart attacks, stroke, and chest pain (angina), but in this case it may be used only under medical supervision.

Do not take the medication if you are allergic to aspirin, as well as in the following cases:

• after a recent gastric or intestinal bleeding;
• if you suffer from a bleeding disorder such as hemophilia;
• if you are allergic to NSAIDs (nonsteroidal anti-inflammatory drugs) such as Advil, Motrin, ALEV, orudis, Indocin, Lodin, Voltaren Voltaren - relieve inflammation and pain , Toradol, NCSM, relafen, Feld.

Precautions and special instructions

If you suffer from any of the following conditions, you may need a dose adjustment of aspirin:

• asthma or seasonal allergies;
• gastric ulcer and duodenal ulcer in the acute phase and in history;
• hepatic impairment;
• renal insufficiency;
• bleeding or blood clotting problems;
• heart disease, high blood pressure, congestive heart failure;
• gout
• polyps in the nose.

If you take aspirin to prevent heart attack or stroke, do not take simultaneously with ibuprofen (Advil, Motrin). Ibuprofen blocks the blood-thinning effects of aspirin and making it ineffective. If you must take the two drugs, the interval between doses of ibuprofen and aspirin exceed eight hours. Aspirin may be harmful to the heart of a child, and also cause a decrease in birth weight or have other dangerous effects on the fetus. Tell your doctor if you are expecting a child or plan to become pregnant before taking aspirin. During the period of breast-feeding while taking aspirin in high doses interruption of breastfeeding Breast-feeding: feed - and no nails!   usually not required. But aspirin passes into breast milk, it should be taken with caution and only under medical supervision.

Drug Interactions

Before you start taking aspirin, tell your doctor if you are taking any antidepressants, such as citalopram (Celexa), duloxetine (Cymbalta), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem, Symbyax), fluvoxamine (Luvox), paroxetine (Paxil), sertraline (Zoloft) or venlafaxine (Effexor). Acceptance of any of these drugs with aspirin may cause bleeding and bruising.

In addition, before taking aspirin, consult your doctor if you take:

• Blood thinners such as warfarin Warfarin - indirect anticoagulants ;
• Other salicylates, e.g., choline salicylate, and / or magnesium salicylate, or salsasalat.

In addition, it is recommended, but not required, consult your doctor if you plan to take both aspirin and a variety of vitamins, minerals, herbs.

How to receive

• Take aspirin, in full accordance with the directions on the label or your doctor prescribed. Do not increase or decrease the dose of the drug in its sole discretion, and do not stop taking aspirin ahead of time, even if the improvement.
• It is recommended to take aspirin with a glass of water. Aspirin with food or milk reduces the burden on the stomach. The tablets in the enteric coating designed for this purpose, but you can make them with food or milk, if desired. Enteric coated aspirin should not crush, chew, break, or open. Swallow the tablets whole with water or milk, so as not to damage the special coating to protect the stomach.
• Chewable aspirin should be chewed before swallowing. Orally disintegrating tablets should be stored in the packaging until the time of use. Before using dry hands, remove the tablet from the package and put it in his mouth. She immediately begins to dissolve, it does not need to drink water. Do not swallow the tablet whole. Not chewing a tablet, wait until it is completely dissolved in the mouth.
• Before surgery be sure to tell the surgeon in advance that you are taking aspirin. Perhaps at some time you have to give up taking the medicine.
• Do not take aspirin if opening a bottle of pills, feel strongly acidic (vinegar) odor. Rather, the drug is not spoiled, and effective. Store aspirin at room temperature in a cool dry place.

Missed dose

Because Aspirin is often used regularly, and when necessary, it can be taken off-track. If you use medication regularly, take the missed dose as soon as you remember about it. If the close time for your next dose, skip the missed dose and comply with the treatment schedule. Do not take extra dose to compensate missed.

Metronidazole - an antibiotic that destroys harmful bacteria in the body. Metronidazole is used to treat bacterial infections of the genital organs, gastrointestinal and respiratory tract, skin and joints. Metronidazole is not used for the treatment of vaginal fungal infections Fungal infection: to prevent and defeat .

Important information about metronidazole

Take metronidazole strictly in accordance with doctor's instructions for the recommended period.

Furthermore, failure and irregular dosing reception metronidazole can lead to the formation of bacterial antibiotic resistance Antibiotics - whether they will help you in the foreseeable future? .

Metronidazole is not used for the treatment of common viral infections such as colds or flu. During treatment with metronidazole should avoid alcohol, plus the 48 hours after the last dose, as a result of violation of ethanol oxidation can occur accumulation of acetaldehyde. As a result, it may cause side effects: heart palpitations, redness and itching of the skin, nausea and vomiting.

What you need to know before taking metronidazole

Metronidazole should not take persons suffering from intolerance to metronidazole or preparations, as well as pregnant women (up to 12 weeks) and breastfeeding women. Be sure to tell your doctor if you are expecting a child or are planning a pregnancy.

Also tell your doctor if you are allergic to any drugs, as well as the following diseases:

• diseases of the gastrointestinal tract, such as Crohn's disease;
• diseases of the hematopoietic system, such as anemia (lack of red blood cells), or leukemia (lack of white blood cells);
• incoordination, organic lesions of the nervous system (including epilepsy);
• severe hepatic and renal failure Kidney failure - when treatment is vital ;
• nervous disorders.

Metronidazole should not be taken in the I trimester of pregnancy. Use of the drug in the II and III trimester is possible only when the intended benefits to the mother outweighs the potential risk to the fetus.

If necessary, use of metronidazole during lactation breastfeeding should stop for a while, as the drug passes into breast milk and may harm a child's health.

Dosage and method of administration of metronidazole

If trichomoniasis into adults administered in a single dose of 250 mg in the morning and evening for 10 days. After completing the course of treatment should be carried out several control laboratory tests (every 3-4 weeks).

When amebiasis adults appoint 250 mg 3 times / day. The course of treatment - 5-10 days; children dose set based 35-50 mg / kg / day. The daily dose should be divided into 3 doses. The course of treatment - 10 days.

When giardiasis Giardiasis - recommend a full examination   Inside adults and children over 10 years prescribed 500 mg / day; children aged 6-10 years - 375 mg / day; 2-5 years - 250 mg / day. The daily dose should be divided into 2 doses. The course of treatment - 5-10 days. After completing the course of treatment should be carried out several control laboratory tests. If necessary, treatment can be repeated after 4-6 weeks.

For the treatment of infections caused by anaerobic bacteria, adults and children over 12 years of drug administered intravenously every 8 hours, 100 ml 0, 5% solution (500 mg). Infusion was performed at 5 ml / min. The maximum daily dose for intravenous administration - 4 years course of infusion therapy is 7-10 days, if necessary = 2-3 weeks. Children under the age of 12 a dose for intravenous administration set the rate of 7, 5 mg / kg body weight (1, 5 ml of 0, 5% solution of metronidazole) every 8 hours. The drug is administered intravenously, slowly. Metronidazole also appointed into a single dose of 250 - 500 mg.

For the prevention of infections caused by anaerobic bacteria (before surgery on the abdomen, in obstetric practice), the use of metronidazole infusion solution should begin in 5-10 minutes prior to surgery. Adults and children over 12 years, the drug is administered at a dose of 500 mg (100 ml 0, 5% solution) / drip slowly through the infusion is repeated 8 hours. Prophylactic drug use no more than 12 hours after surgery. Children under 12 years of age a dose for intravenous administration set rate of 7, 5 mg / kg body weight (1, 0 5 ml, 5% solution of metronidazole).

Metronidazole also appointed inside. Adults and children over 12 years, the first single dose of 1 g (4 tablets. 250 mg), followed by 250 mg 3 times a day during or after a meal, before preoperative fasting; children 5 to 12 years, 125 mg every 8 hours for 2 days.

Store metronidazole should at room temperature in a dry, dark place. Do not use after the expiration date printed on the package.

Is it possible to skip the reception of metronidazole?

If you forget to take metronidazole, correct this mistake as soon as possible. When it is time to take the next dose, do not double the dose to make up for a missed dose of medication.

What to do in case of excess doses of metronidazole?

In the case of metronidazole overdose contact your doctor immediately. Symptoms of overdose of metronidazole: convulsions, peripheral neuropathy; after a single oral administration of 15 grams of metronidazole nausea, vomiting and incoordination.

Specific recommendations for the treatment of metronidazole

Side effects: heart palpitations, redness and itching of the skin, nausea and vomiting.

Carefully read the information on the packaging of medicines or foods to make sure that they do not contain alcohol.

Taking antibiotics can cause diarrhea, which may indicate a new infection. When diarrhea, stop taking metronidazole and seek medical advice. Funds from diarrhea can be taken only on doctor's advice.